Therapeutic potential of human dental pulp stem cells in cardiac repair, a new hope for interdisciplinary regenerative medicine? A systematic review

Caulet, Emilie Patricia Stephanie

Author/s: Caulet, Emilie Patricia Stephanie

Advisor/s: Carceller Zazo, María del Carmen

Keyword/s: Myocardial infarction; Human dental pulp stem cells; Stem cell therapy; Cardiac repair; Cardiac function improvem

Degree: Grado en Odontología

Date of defense: 2023-07

Type of content: TFG

URI: https://hdl.handle.net/20.500.12880/5660

Abstract:

Introduction: Over the past 2 decades, mesenchymal stem cells (MSCs) have become the basis of the emerging field of regenerative medicine due to their self-renewal and multilineage differentiation abilities. Despite treatment advancements, myocardial infarction remains a significant cause of mortality and disabilities. Dental pulp stem cells (DPSCs) offer promising regenerative properties for cardiac regeneration. This review aims to assess the improvement achieved by human DPSCs and stem cells from human exfoliated deciduous teeth (SHED) in cardiac function, infarct size reduction, and angiogenesis compared to human bone marrow MSCs (hBMMSC) in rodent models of myocardial infarction.