@misc{20.500.12880/494,
year = {2021},
month = {6},
url = {http://hdl.handle.net/20.500.12880/494},
abstract = {Introduction: The oral microbiota is a wide ecosystem formed by microorganisms including bacteria, virus, fungi present in the oral cavity (saliva, dental plaque, mouth mucosa, etc. …). Oral microbiota is composed by different species existent since child’s birth including Bacteroides, Firmicutes and Streptococci family and fungi such as Candida albicans. New techniques for studying microbiota have been developed thanks to the DNA sequencing. Objectives: The primary objective proposed in this thesis is to study the oral microbiota and the techniques used to sequence the DNA. The secondary objective is to study oral microbiota as an effective predictor of oral diseases (caries, periodontal diseases, aphthous and oral cancer) and systemic diseases (Diabetes and Lupus Erythematosus) and to characterize the most important microbiota biomarkers associated to these diseases. Materials and methods: To study the relation between the oral microbiota and oral and systemic diseases, a comprehensive search, through Medline, Pubmed and Google Scholar, was conducted. Results and discussion: In deep dental caries high level of Streptococcus mutans, Streptococcus spp. and Lactobacillus were found; P.gingivalis, Treponema and Filifactor Alocis are the most represented in early and severe periodontitis; Synergisteae, Actinomyces, Firmicutes and Proteobacteria in Recurrent Aphtous Stomatitis; Streptococcus and Capnocytophaga families in oral cancer. In diabetic patients with periodontal diseases, P. gingivalis, T. forsythensis were highly represented and Lactobacillus and Veillonella in patients with advanced systemic lupus erythematosus with ulcerative lesions. Conclusions: The evolution of techniques, such as 16S rRNA sequence analysis, has made possible to discover many bacterial species in the oral cavity. These findings help healthcare professionals to properly diagnose and treat oral and systemic diseases.},
abstract = {Introducción: la microbiota bucal es un amplio ecosistema formado por microorganismos que incluyen bacterias, virus y fungos presentes en la cavidad bucal (saliva, placa dental, mucosa bucal, etc…). La microbiota oral está compuesta por diferentes especies existentes desde el nacimiento, incluyendo la familia Bacteroides, Firmicutes y Estreptococo y fungos como Cándida albicas. Se han desarrollado nuevas técnicas para el estudio de la microbiota gracias a la secuenciación del ADN. Objetivos: el objetivo principal propuesto en esta tesis es el estudio de la microbiota oral y las técnicas utilizadas para secuenciar el ADN. El objetivo secundario es el estudio de la microbiota oral como predictor eficaz de enfermedades bucales (caries, enfermedades periodontales, aftas y cáncer bucal) y enfermedades sistémicas (Diabetes y Lupus Eritematoso) y caracterizar los biomarcadores de microbiota más importantes asociados a dichas enfermedades. Materiales y métodos: para estudiar la relación entre la microbiota y las enfermedades orales y sistémicas, se realizó una búsqueda integral, a través de Medline, Pubmed y Google Scholar. Resultados y discusión: en lesiones cariosas profundas las bacterias más frecuentes son Estreptococos mutan, Estreptococos spp. y Lactobacilos; P.gingivalis, Treponema y Filifactor Alocas son los las bacterias más representadas en la periodontitis temprana y severa; Prevotella, Actinomices, Firmecitas y Proteobacteria en la estomatitis aftosa recurrente; Las familias de Estreptococos y Capnocytophaga se hallaron en el cáncer oral. En pacientes diabéticos con enfermedades periodontales se encontraron muy representados P. gingivalis y T.forsythensis y Lactobacilos y Veillonella en pacientes con lupus eritematoso sistémico avanzado con lesiones ulcerativas.},
title = {Oral Microbiota-- Predictor of Oral and Systemic Diseases},
keywords = {Odontología},
keywords = {Boca},
keywords = {Microorganismos},
keywords = {Enfermedades},
author = {Ghassemi, Sina},
}